Iridoid glycosides an overview sciencedirect topics. Iridoid glycosides from gmelina arborea sciencedirect. Gmelinosides al, twelve acylated iridoid glycosides from gmelina arborea. Chemical constituents from gmelina arborea bark and their. Jan 06, 2020 gmelina arborea is an important medicinal plant indicated in the traditional indian medicine. In vitro cytotoxicity of gmelina arborea roxb gambhari on hl60 cell lines. Iridoid glycosides of chelone glabra scrophulariaceae and. Toxicological evaluation of the methanol extract of gmelina. Request pdf iridoid glycosides from gmelina arborea three iridoid glycosides 6o3obenzoylalphalrhamnopyranosylcatalpol 1a. In contrast with other monoterpene cyclases, iridoid synthase uses 8oxogeranial as a substrate. Antifungal activity of iridoid glycosides from the heartwood. Evaluation of diuretic activity of gmelina arborea roxb.
Gmelinosides al, twelve acylated iridoid glycosides from. The cytoprotective activity of 11 selected compounds 18, 10, 11, and 15 against ccl 4induced cytotoxicity on liver was determined. Antidiabetic activity of aqueous extract of gmelina arborea bark in rats. Rosazzagmelinosides al, 12 acylated iridoid glycosides from gmelina arborea journal of natural products, 61 6 1998, pp. An ingredient of ayurvedc preparation known as dashamularishta references.
Acylated iridoid glycosides and acylated rhamnopyranoses. Nine acylated iridoid glycosides 19, five acylated rhamnopyranoses 1014 and verbascoside 15 were isolated from gmelina arborea flowers, including 5 new compounds 1, 2, and 1012. Antioxidant and cytotoxic activities of flavonoidal. Arational approach for quality assessment of indian medicinal plant gambhari gmelina arborea. Iridoid and phenylethanoid glycosides from euphrasia pectinata. Gmelina arborea grows on different localities and prefers moist fertile valleys with 7504500mm rainfall. Iridoid glycosides from gmelina philippensis sciencedirect. Iridoid glycosides fraction isolated from veronica ciliata. It does not thrive on illdrained soils, drought also reduces it to a shrubby form. Phytochemical screening ethanol extract of barks in.
For the repeated dose toxicity study, the wistar rats of either sex were orally administered with me of g. Iridoid glycoside based quantitative chromatographic fingerprint analysis. Here, in this study we have developed a simple and fast hplcdad method for the total comparative estimation of these two major iridoids from different parts of. The structures of the compounds were determined through 1d and 2d nmr spectroscopic data analysis. The phytochemical analysis revealed the concentrations mgg. David punitha, 1department of botany, providence college for women, coonoor, the nilgiris angamuthu thandavamoorthy, karuppanan arumugasamy2 uthaman danya2, madathupatti ramanathan udhayasankar2 and thimmayan baluprakash2. Toxicological studies on aqueous extract of gmelina arborea in.
Evaluation of five medicinal plants used in diarrhoeal treatment in nigeria. Oct 14, 2019 iridoid glycosides from gmelina arborea. The roots, fruits and the leaves of gambhari have great medicinal value. On the basis of the spectroscopic data and a comparison with the published data in the literature, compound 1 was identi ed as aucubin5. A new iridoid glycoside and no production inhibitory. The structures of eight new iridoid and two new phenylethanoid glycosides were elucidated on the basis of chemical and spectroscopic evidences. Iridoid glycosides from gmelina arborea request pdf. Toxicological evaluation of the methanol extract of. Gmelinoiridoside, a new iridoid glycoside from gmelina. Authors personal copy iridoid glycosides fromgmelina arborea neerja tiwari, akhilesh k. This plant is commonly known as bhadraparni or gambhari in orissa.
Almost all parts of this tree are used in folk medicine for. Comparative estimation of major iridoid glucosides from. Abdulkarim a, sadiq y, gabriel oa, abdulkadir uz, ezzeldin am. Acylated iridoid glycosides and acylated rhamnopyranoses from.
A bioassayguided fractionation and chemical investigation of the gmelina arborea leaves verbenaceae resulted in the isolation and characterization of six known flavonoids 1, 37 along with new flavone glycoside 2, identified as. The name arborea means treelike, derived from the latin word arbor means tree. Kashmarya, dashamula, gambhari, gmelina arborea roxb, verbenaceae. Effects of gmelina arborea extract on experimentally induced diabetes. The initial phase is attributed to the release of histamine and serotonin. Antifungal activity of iridoid glycosides from the heartwood of gmelina arborea, holzforschung. Pages in category iridoid glycosides the following 11 pages are in this category, out of 11 total. Detection of proteins and amino acids a small quantity of extract was dissolved in few ml of water and they were subjected to millions test, ninhydrin test, biuret test as given below.
Incarvillea emodi bignoniaceae is a rich source of bioactive iridoid glucosides. Luteolin, indole alkaloids, and iridoid glycosides have been isolated from the leaves. Otranspcoumaroylrhamnopyranosylcatalpol 3, 2pyrrolidinone 4, syringaresinol 5, squalene 6, and a mixture of. Iridoid, phenylethanoid and monoterpene glycosides from. Effect of gmelina arborea roxb in experimentally induced. Evaluation of five medicinal plants used in diarrhoeal treatment in. Feb 01, 2005 read antifungal activity of iridoid glycosides from the heartwood of gmelina arborea, holzforschung international journal of the biology, chemistry, physics and technology of wood on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
Gupta central institute of medicinal and aromatic plants, analytical chemistry division, p. Iridoid glycosides from gmelina philippensis request pdf. Otranspcoumaroylrhamnopyranosylcatalpol 3, 2pyrrolidinone 4, syringaresinol 5, squalene 6, and a. Scrophulariaceae, eighteen acylated iridoid glycosides and nine phenylethanoid glycosides were isolated.
A summary of results from three decades of research and a discussion of how to use them. There was no difference in the iridoid glycoside content of damaged compared to undamaged plants, nor was there a difference between plants collected from a population in leverett. Medicinal properties of crude extracts of gmelina arborea have been investigated using model animal systems. Pdf iridoid glycosides from gmelina arborea akhilesh k.
On the composition in secondary metabolites and the antioxidant activity of crude extracts from gmelina arborea roxb. The major chemical components including 5 new compounds of g. Till now a large number of phytoconstituents have been isolated from gmelina arborea. It was reported that lignans from the heartwood of g. Catechin glycosides from ulmus davidiana springerlink. L, twelve acylated iridoid glycosides from gmelina arborea.
These bitter principles stimulates the release of gastrin in the digestive system, which in turn stimulates the secretions of bile and other digestive chemicals. The roots, leaves, flowers, fruits and bark are used for treating different ailments in traditional medicine. Pdf iridoid glycosides from gmelina arborea neerja. The genus was named after 18 th century german botanist j.
L, twelve acylated iridoid glycosides from gmelina. Gmelina arborea flower is a medicinaledible plants in xishuangbanna, china. Gmelina arborea roxb verbenaceae is a wellknown medicinal plant in the ayurveda, an ancient indian system of medicine. An overview on phytochemistry and pharmacological properties of gmelina arborea abstract. Gmelina consists of about 33 species of trees and shrubs and is distributed from pakistan and india, sri lanka and southern china through the malesian archipelago towards northern and western australia, fiji, new zealand and new caledonia. Nov 26, 2014 a new iridoid glycoside, gmelinoiridoside 1, has been isolated from the leaves of gmelina philippensis, together with seven known compounds, 6o. Heartwood of the plant showed presence of different lignans such as arboreol, isoarboreol, methyl arboreol, arborone, gmelanone, gummadiol, and 7oxodihydrogmelinol1820. Iridoid, phenylethanoid and monoterpene glycosides isolated from p. Potent in vitro cytotoxic effect of gmelina arborea roxb.
Iridoid and phenylpropanoid glycosides from the roots of. The effects of aqueous leaf extract of gmelina arborea on. Gambhari gmelina arborea information, medicinal uses and. As medicine it has been used in ayurveda since ancient times in ulcer, diarrhoea, thirst, anaemia, leprosy, vaginal discharges, piles, fever and varieties of ailments.
Verbenaceae is a deciduous broadleaved tree widely distributed from southeast asia to south asia greaves 1981 and all parts of this plant are. Verbenaceae is a beautiful fast growing tree distributed chiefly in southeast asia and tropical africa. Antifungal activity of iridoid glycosides from the. A large number of phytoconstituents have been identified in different parts of g. Relevance of tumour necrosis factoralpha for phytochemistrry inflammatory and nociceptive responses evoked by carrageenan in the mouse paw. Antifungal activity of iridoid glycosides from the heartwood of gmelina arborea. Effects of gmelina arborea extract on experimentally.
The wood is also used for manufacturing tea chests and general purpose plywood, blackboards, frame core and cross bands of flush door. Dec 01, 2016 gambhari gmelina arborea information, medicinal uses and more gambhari is a medicinal tree mentioned in all classical texts of ayurveda. The effects of aqueous leaf extract of gmelina arborea on the. Gmelina arborea an important medicinal plant is one of the most widely cultivated species of the family verbenaceae. Analysis ofchelone glabra scrophulariaceae by gas chromatography showed that leaves of this plant contained primarily the iridoid glycoside catalpol, and in a few individuals some aucubin was also detected. Acylated iridoid glycosides and acylated rhamnopyranoses from gmelina arborea flowers. Their structures were identi ed as acteoside 215, leucosceptoside a 515, martynoside 616, forsythoside b 717 and betulalbuside 818 by. The species are also planted as a shade tree for coffee and cocoa. The gmelina arborea wood is used for pulp, particle board, plywood, matches, carpentry and packing. Phytochemical studies demonstrated that iridoid glycosides are the main active fraction of the leaves. Iridoid glycosides are a large group of naturally occurring monoterpenoids with a glucose moiety attached to c1 in the pyran ring song et al. Larvicidal activity of gmelina arborea fruit extract. It is an approved timber for handles of tennis rackets, frames and reinforcements of carom boards and packing cases and crates.
Uses, benefits, properties, and effects of iridoid glycosides. The crude extract from leaves was observed to have antioxidant activity in vitro naik et al. The effects on body weight, food and water consumption. From the 1buohsoluble fraction of a meoh extract of the leaves of russelia equisetiformis, one new iridoid glucoside was isolated along with 24 known compounds, comprising iridoids and iridoid glucosides, phenyl propane glucosides, phenyl ethanoids, lignan glucosides, and flavonoid glucosides. Learn about its medicinal uses, botanical details and scientific classification. Acylated iridoid and phenylethanoid glycosides from the. Iridoid glycosides have laxative and antimicrobal properties. The iridoid glycoside, syringopicroside 48, is the main active constituent and has been shown to possess antiinflammatory, broadspectrum antimicrobial, antiviral, and. Compounds 1, 2, 4, 7, 8 and 15 displayed hepatoprotective activity. Formation of blue colour showed the presence of glycosides. Relevance of tumour necrosis factoralpha for phytochemistrry inflammatory and nociceptive responses. The extract of gmelina arborea increased the haemoglobin concentration and packed cell volume of rats after twentyeight 28 days of feeding p gmelina arborea is rich in carbohydrate and calcium table 1, hence its significance in haemopoiesis.
Compounds 2 and 58 were obtained as amorphous compounds. Growth, biomass productivity and carbon sequestration efficacy, plant sci. Iridoid glycosides are a group of compounds that have a structure related to iridodial figure 11. A rational approach for quality assessment of indian medicinal plant gambhari gmelina arborea. The iridoid ring scaffold is synthesized, in plants, by the enzyme iridoid synthase. Gmelina arborea is an unarmed deciduous medium size to large plant about 1230 m, height 60100 cm diameter with white spikes4. The structure of the new compound was elucidated to be 10ocinnamoyl sinuatol. Gmelina arborea is a popular timber for picture and slate frames, turnery articles and various types of brush backs, brush handles and toys also for handles of chisels, files, saws, screw drivers, sickles etc. Antifungal activity of iridoid glycosides from the heartwood of gmelina arborea antifungal activity of iridoid glycosides from the heartwood of gmelina arborea kawamura, fumio. Volume 69, issue 12, september 2008, pages 23872390. Chemical constituents from gmelina arborea bark and their antioxidant activity. These occupy an important position in the field of natural product chemistry and biology, as they provide a structural link between terpenoids and indole alkaloids and display a broad spectrum of biological activities sticher. There are many that believe that iridoid glycosides. Cimap, kukrail picnic spot road, lucknow, uttar pradesh 226015, india article info article history.
Dxylopyranosideshanzhiside methyl ester 1 along with six known compounds. Larvicidal activity of gmelina arborea fruit extract against dengue vector aedes aegypti mosquito. Pdf iridoid glycosides from gmelina arborea ram kishor. Bark and fruit extracts of gmelina arborea protect liver. Stachytarpheta angustifolia, nbutanol, root extract, iridoid glucosides introduction iridoid glycosides are large group of naturally occurring monoterpeniod with a glucose moiety attached at c1 in the pyran ring song et al, 2006. The enzyme uses a twostep mechanism, with an initial nadph dependent reduction step followed by a cyclization step that occurs through either a dielsalder. The presence of glycosides of flavones were also indicated 10. Pdf iridoid glycosidebased quantitative chromatographic. Effects of gmelina aborea fruit juice on histopatholology of. Sixteen new acylated iridoid glycosides, called buddlejosides a1a16, were isolated from buddleka japonica hemsl. The literature suggests use of the plant in treatment of scorpion sting, snakebites, and diabetes. These compounds were structurally characterized using a variety of spectral methods uv, ir, 1h, c nmr 26. A new iridoid glycoside, gmelinoiridoside 1, has been isolated from the leaves of gmelina philippensis, together with seven known compounds, 6o.
It is also used for construction of boards, carving and musical instruments. Acylated iridoid glycosides and acylated rhamnopyranoses from gmelina arborea flowers wei gu, xiaojiang hao, hongxin liu, yuehu wang, and chunlin long phytochemistry letters, 20, volume 6, number 4, page 681. The powdered bark was used to prepare the ae and me. Larvicidal activity of gmelina arborea fruit extract against.
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